Netherlands

The Netherlands Brain Bank (NBB)

The Netherlands Brain Bank (NBB) is a non-profit organization that collects human brain tissue of donors with a variety of neurological and psychiatric disorders, but also of non-diseased donors. This brain tissue, together with an anonymized summary of a donor’s medical record, is sent to scientific researchers worldwide, with the ultimate aim of increasing our understanding of the human brain and to develop therapies for neurological and psychiatric diseases, including (non-exhaustive): neurological disorders, such as, Alzheimer´s disease, multiple sclerosis, frontotemporal dementia, vascular dementia, Parkinson’s disease, Lewy body dementia, progressive suprenuclear palsy, multi system atrophy and huntinton´s disease; and phychiatric disorders, such as, major depression, bipolar disorder and schizophrenia.

Key facts

Name of the connected EIT Health partner:
Number of individuals: >4500 donors included in the collection, >5000 donors currently registrered as donor
Biobank confirmed willingness to provide samples/data for EIT Health studies: Yes. An MTA signed by the NBB and receiving legal entity is required to gain access to samples from the NBB.
Contact person(s) and contact data
(e-mail address, tel. no) for access purposes:		 Mignon de Goeij, General operations, enbb@nin.knaw.nl, +31 20 5665499; Mark Mizee Industry contact, m.mizee@nin.knaw.nl, +31 20 5665499
Number of samples:
Sample type: Tissue;Whole blood;Plasma;Cells;Liquor;DNA; Neuropathological diagnosis;Questionnaire data;Imaging data;Clinical data;Genomics;Epigenomics
Website: https://www.brainbank.nl/
Website:

General information

Type of biobank: Clinical/disease specific.
If longitudinal the frequency:
Link to central portal to seek samples and data: https://www.e-nbb.org/
Broad consent: Yes. See here
Option to recall donors: No
Option to recall family members: No

Biobank access procedure:

Major terms for access: Applicants are asked to complete the application procedure (sample selection and application template)
Ethical and legal compliance: Ethical declaration
Speed and reliability of delivery: To be supplemented shortly
Pricing: To be supplemented shortly

Quality management system:

Storage: Sample and data procedure
Compliance with international standards: https://www.brainbank.nl/about-us/brain-net-europe/d
Current ISO certificates:

Data:

Clinical data linked to samples: For each donor that comes to autopsy, the full clinical history is collected from various sources. All information deemed relevant is compiled into an anonimized clinical history report. This is complemented by a final diagnosis based on standardized neuropathological analysis (specific for each indication). A genomics database containing genetic risk profiles for all NBB donors is under development. Many NBB donors were part of longitudinal research cohorts before passing. Where relevant, applicants will receive the option to contact the cohort leader for a specific disease indication, to explore collaboration potential on data collected in these registers.
Data standards:
Data security rules:

Biobank related service:

Research support, what type of expertise?:
Core facility services; what type? Link?:
Queries from national health registers:
Links to the model contract and MTA:

IP:

IP rules, what is negotiable?:
Requirements to study results (access etc.):
Participant’s right to the information:
Number of access contracts with industry:

COVID-19 samples:

Access to biological samples from patients with COVID-19?

  • Serum
  • Full blood (for RNA extraction)
  • EDTA-Full blood (for DNA extraction)
  • EDTA-Plasma
  • Citrate-Plasma
  • PBMC (Peripheral Blood Mononuclear Cells)
  • Nasopharyngeal aspirate
  • Tracheal aspirate
Contact person(s) and contact data (e-mail address, tel. no) for access purposes